11/12/2023 0 Comments Datathief to digitizeThus, the first objective of this analysis was to assess the general usage of the data digitizing software for QSP and PBPK modeling. Consequently, these factors can potentially interfere with model development and evaluation processes and ultimately lead to false predictions and questionable model‐based decisions. In addition, little is known about the extent of discrepancy between reported and graphically presented data that is typically only revealed after post hoc digitization and the nature of these errors and confounding factors when it comes to the digitization process. Moreover, to the best of our knowledge, there is no systematic evaluation of the accuracy and precision of these software solutions, nor have any interfering factors that could potentially bias the digitized output been identified. 14 However, neither for them nor for QSP or PBPK modeling is information available regarding the importance and use of digitizing software. 10, 11, 12, 13 These software solutions have been in active use for some time for the well‐established population PK approaches. 3, 4, 5, 6, 7, 8, 9 Fortunately, several off‐the‐shelf digitization software packages that allow the extraction of numerical information from their two‐dimensional graphical representation are currently available. To illustrate the scale of this issue, it should be noted that PBPK projects not uncommonly rely on extracted data gathered from up to 50 articles. Despite the potential to automatically data‐mine population average pharmacokinetic (PK) data for certain applications, 2 data extraction from graphical representations still requires manual efforts. As a result, researchers must extract the information of interest from the graphical representation to use the data for their modeling approaches. Unfortunately, published data are typically presented in aggregate form as plots or graphs without providing access to the underlying raw, uncondensed data. 1 However, for model development, time‐dependent data of pharmacological relevant processes are a crucial requirement. However, because the greatest pitfall comes from pre‐existing errors, we recommend always making published data available as raw values.ĭuring the past few years, quantitative systems pharmacology (QSP) and especially physiologically‐based pharmacokinetics modeling (PBPK) have proven to be an important cornerstone of model‐informed drug discovery and development. Our findings suggest that data digitizing is precise and important. Analysis of 181 literature peak plasma concentration values revealed a considerable discrepancy between reported and post hoc digitized data with 85% having ζ > 5%. Although significant, no relevant confounders were found (mean ζ ± SD circles = 0.69% ± 0.68% vs. Accuracy, precision, confounder influence, and variability were investigated using scaled median symmetric accuracy (ζ), thus finding excellent accuracy (mean ζ = 0.99%). To quantify their relevance, a literature search revealed a remarkable mean increase of 16% per year in publications citing digitizing software together with QSP or PBPK. These solutions take into account a variety of tastes and provide novel ways to the digitalization of data, which, in the end, contribute to more accurate analysis and decision-making.In quantitative systems pharmacology (QSP) and physiologically‐based pharmacokinetic (PBPK) modeling, data digitizing is a valuable tool to extract numerical information from published data presented as graphs. Why Look for DataThief III Alternatives?Įven if DataThief III has done a good job of fulfilling its aim, investigating other options may lead to the discovery of novel perspectives and enhanced functions. Other good alternatives to DataThief III that are similar to its features are Engauge Digitizer, Plot Digitizer, PlotDigitizer, and g3data, all of which give the user more choices. The most important alternative is WebPlotDigitizer, which stands out because it is free and uses an open-source platform. This makes it very flexible and has led to more than 10 rival solutions. It works on multiple platforms, including Windows, Linux, Mac, web-based systems, and self-hosted setups. This makes it a unique tool in the world of development apps. Engauge Digitizer, Plot Digitizer, PlotDigitizer, and g3data are also good choices that are similar to DataThief III.ĭataThief III is a piece of software that is designed to decode and extract data points from graphs. WebPlotDigitizer stands out among these options because it is both free to use and open-source. It belongs to the category of development apps and has more than 10 alternatives on Windows, Linux, Mac, online platforms, and self-hosted options. Why Look for DataThief III Alternatives?ĭataThief III is a well-known piece of software that can be used to reverse engineer plots and get data points from them.
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